1. PRODUCT AND COMPANY IDENTIFICATION
| Product name | RiboLyse |
| Recommended use | Laboratory chemicals |
| Restrictions on use | Not specified |
| Company | Ribology Pty Ltd |
| Address | 351 Oran Park Drive Oran Park NSW Australia 2570 |
| Website | http://ribology.com.au |
| E-mail address | [email protected] |
| Emergency telephone | CHEMTREC: +1 703-527-3887 CHEMTREC AUS: +(61)-290372994 |
2. HAZARDS IDENTIFICATION
GHS Classification
| Acute toxicity (Oral) | Category 4 |
| Serious eye damage/eye irritation | Category 1 |
| Long-term (chronic) aquatic hazard | Category 3 |
GHS label elements
| Hazard pictograms | [GHS pictograms for acute toxicity and corrosion would appear here] |
| Signal word | Danger |
| Hazard statements | H302 Harmful if swallowed. H318 Causes serious eye damage. H412 Harmful to aquatic life with long lasting effects. |
| Precautionary statements | Prevention: P273 Avoid release to the environment. P280 Wear protective gloves/ protective clothing/ eye protection/ face protection. Response: P305 + P351 + P338 + P310 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER/ doctor. |
Other hazards which do not result in classification
No data available.
3. COMPOSITION/INFORMATION ON INGREDIENTS
| Substance / Mixture | Mixture |
Components
| Chemical name | Common Name | CAS-No. | Concentration (% w/w) |
|---|---|---|---|
| guanidinium thiocyanate | guanidinium thiocyanate | 593-84-0 | ≥ 45 - < 50 |
| water | water | 7732-18-5 | ≥ 50 - < 55 |
4. FIRST AID MEASURES
| General advice | Move out of dangerous area. Show this safety data sheet to the doctor in attendance. |
| In case of eye contact | Small amounts splashed into eyes can cause irreversible tissue damage and blindness. In the case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Remove contact lenses. Protect unharmed eye. |
| In case of skin contact | Wash off immediately with soap and plenty of water while removing all contaminated clothes and shoes. If symptoms persist, call a physician. |
| If inhaled | If unconscious, place in recovery position and seek medical advice. If symptoms persist, call a physician. |
| If swallowed | If accidentally swallowed obtain immediate medical attention. Rinse mouth with water. Never give anything by mouth to an unconscious person. |
| Most important symptoms and effects, both acute and delayed | No information available. Harmful if swallowed. May be harmful in contact with skin or if inhaled. Causes serious eye damage. |
| Notes to physician | No information available. |
5. FIREFIGHTING MEASURES
Suitable and unsuitable extinguishing media
| Suitable extinguishing media | Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. |
| Specific hazards during firefighting | Do not allow run-off from fire fighting to enter drains or water courses. Exposure to decomposition products may be a hazard to health. |
| Hazardous combustion products | Carbon oxides Sulphur oxides |
Special protective equipment for firefighters
| Specific extinguishing methods | In the event of fire and/or explosion do not breathe fumes. |
| Special protective equipment for firefighters | Wear self-contained breathing apparatus for firefighting if necessary. |
6. ACCIDENTAL RELEASE MEASURES
| Personal precautions, protective equipment and emergency procedures | Use personal protective equipment. Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray. |
| Environmental precautions | Prevent product from entering drains. Prevent further leakage or spillage if safe to do so. |
| Methods and materials for containment and cleaning up | Soak up with inert absorbent material (e.g. sand, silica gel, acid binder, universal binder, sawdust). Keep in suitable, closed containers for disposal. Unsuitable cleaning agents: sodium hypochlorite |
7. HANDLING AND STORAGE
| Advice on protection against fire and explosion | Normal measures for preventive fire protection. |
| Advice on safe handling | Do not breathe vapours/dust. Avoid contact with skin and eyes. For personal protection see section 8. Smoking, eating and drinking should be prohibited in the application area. Dispose of rinse water in accordance with local and national regulations. |
| Conditions for safe storage | Keep container tightly closed in a dry and well-ventilated place. |
| Further information on storage stability | No decomposition if stored and applied as directed. |
8. EXPOSURE CONTROLS/PERSONAL PROTECTION
Components with workplace control parameters
Contains no substances with occupational exposure limit values.
Personal protective equipment
Among the following personal protective equipment, the PPEs which require safety certification need to be certified by SAFE WORK AUSTRALIA.
| Eye protection | Tightly fitting safety goggles Wear face-shield and protective suit for abnormal processing problems. Do not wear contact lenses. |
| Hand protection - Material | Protective gloves |
| Hand protection - Remarks | The choice of an appropriate glove does not only depend on its material but also on other quality features and is different from one producer to the other. Take note of the information given by the producer concerning permeability and break through times, and of special workplace conditions (mechanical strain, duration of contact). |
| Skin and body protection | Choose body protection according to the amount and concentration of the dangerous substance at the work place. Acid-resistant protective clothing Footwear protecting against chemicals |
| Hygiene measures | Keep away from food and drink. Wash hands before breaks and at the end of workday. Ensure adequate ventilation, especially in confined areas. Avoid contact with the skin and the eyes. When using do not eat, drink or smoke. Ensure that eyewash stations and safety showers are close to the workstation location. |
9. PHYSICAL AND CHEMICAL PROPERTIES
| Appearance | liquid |
| Colour | colourless |
| Odour | No data available |
| Odour Threshold | No data available |
| pH | ca. 7 |
| Melting point/range | No data available |
| Boiling point/boiling range | No data available |
| Flash point | No data available |
| Evaporation rate | No data available |
| Burning rate | No data available |
| Upper explosion limit / Upper flammability limit | No data available |
| Lower explosion limit / Lower flammability limit | No data available |
| Vapour pressure | No data available |
| Water solubility | soluble |
| Solubility in other solvents | No data available |
| Relative vapour density | No data available |
| Relative density | No data available |
| Density | ca. 1.09 g/cm³ (ca. 25 °C) |
| Partition coefficient: n-octanol/water | No data available |
| Auto-ignition temperature | No data available |
| Decomposition temperature | No data available |
| Viscosity, dynamic | No data available |
| Viscosity, kinematic | No data available |
| Explosive properties | No data available |
| Oxidizing properties | No data available |
10. STABILITY AND REACTIVITY
| Chemical stability and possibility of hazardous reactions | No decomposition if stored and applied as directed. No decomposition if stored and applied as directed. Stable under recommended storage conditions. Hazardous decomposition products formed under fire conditions. Thiocyanates can develop poisonous gas in contact with strong acids. Keep away from oxidizing agents, and acidic or alkaline products. |
| Conditions to avoid | No data available |
| Incompatible materials | No data available |
| Hazardous decomposition products | No decomposition if stored and applied as directed. |
11. TOXICOLOGICAL INFORMATION
| Information on likely routes of exposure | No data available |
Harmful if swallowed.
May be harmful in contact with skin or if inhaled.
Acute toxicity
RiboLyse
| Acute oral toxicity | Remarks: No data available |
| Acute inhalation toxicity | Remarks: No data available |
| Acute dermal toxicity | Remarks: No data available |
Components:
guanidinium thiocyanate (CAS: 593-84-0):
| Acute toxicity (other routes of administration) | LD50 (Mouse): 300 mg/kg |
water (CAS: 7732-18-5):
| Acute oral toxicity | LD50 Oral (Rat): > 5,000 mg/kg |
Skin corrosion/irritation
| Product | Remarks: May cause skin irritation in susceptible persons. |
Serious eye damage/eye irritation
Causes serious eye damage.
| Product | Remarks: May cause irreversible eye damage. |
Respiratory or skin sensitisation
| Product | Remarks: No data available |
Carcinogenicity
No data available
Germ cell mutagenicity
No data available
Reproductive toxicity
No data available
STOT - single exposure
No data available
STOT - repeated exposure
No data available
Repeated dose toxicity
No data available
Aspiration toxicity
No data available
Experience with human exposure
No data available
Toxicology, Metabolism, Distribution
No data available
Neurological effects
No data available
Further information
No data available
12. ECOLOGICAL INFORMATION
Ecotoxicity
Product
| Toxicity to algae/aquatic plants | Remarks: No data available |
| Toxicity to microorganisms | Remarks: No data available |
Components:
guanidinium thiocyanate (CAS: 593-84-0):
| Toxicity to daphnia and other aquatic invertebrates | EC50 (Daphnia (water flea)): 42.4 mg/l Exposure time: 48 h |
| Toxicity to fish (Chronic toxicity) | NOEC (Poecilia reticulata (guppy)): 25 mg/l Exposure time: 96 d |
Persistence and degradability
No data available
Bioaccumulative Potential
| Product | Remarks: No data available |
Mobility in soil
No data available
Other adverse effects
| Product - Additional ecological information | No data available |
13. DISPOSAL CONSIDERATIONS
Disposal methods
| Waste from residues | The product should not be allowed to enter drains, water courses or the soil. Send to a licensed waste management company. Dispose of as hazardous waste in compliance with local and national regulations. |
| Contaminated packaging | Dispose of as unused product. Do not re-use empty containers. |
Disposal precautions
Dispose of contents and container according to wastes control act. Follow article 13 of the act to dispose the product waste. The product is classified as hazardous waste.
14. TRANSPORT INFORMATION
Special precautions for user
Not applicable
International Regulations
| Regulation | UN Number | Proper Shipping Name | Class | Packing Group | Labels | Other |
|---|---|---|---|---|---|---|
| UNRTDG | Not applicable | Not applicable | Not applicable | Not applicable | Not applicable | Subsidiary risk: Not applicable |
| IATA-DGR | Not applicable | Not applicable | Not applicable | Not applicable | Not applicable | Packing instruction (cargo aircraft): Not applicable Packing instruction (passenger aircraft): Not applicable |
| IMDG-Code | Not applicable | Not applicable | Not applicable | Not applicable | Not applicable | EmS Code: Not applicable Marine pollutant: Not applicable |
Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
Not applicable for product as supplied.
National Regulations
Refer to section 15 for specific national regulation.
15. REGULATORY INFORMATION
National regulatory information
Regulation under the Occupational Safety and Health Act
- Harmful Substances Prohibited from Manufacturing: Not applicable
- Harmful Substances Required Permission for Manufacture: Not applicable
- Harmful Agents to be kept below Occupational Exposure Limits: Not applicable
- Harmful Agents Required to be kept below Permission Levels: Not applicable
- Hazardous substances requiring management: Not applicable
- Special Management Materials: Not applicable
- Controlled Substances Subject to Environment Monitoring: Not applicable
- Controlled Substances Subject to Health Examination: Not applicable
Regulation under the Chemicals Control Act
- Toxic Chemicals: Not applicable
- Restricted Chemicals: Not applicable
- Prohibited Chemicals: Not applicable
- Toxic Release Inventory: Not applicable
- Accident Precaution Chemicals: Not applicable
Dangerous Substances Safety Management Act
Not Applicable to Dangerous Materials
Wastes Control Act
Hazardous waste. Follow article 13 of the act to dispose the product waste.
16. OTHER INFORMATION
Further information
| SDS Number | 600000009760 |
| Issuing date | 2025/11/14 |
| Number of Revision | 1.0 |
| Revision Date | 2025/11/14 |
| Date format | yyyy/mm/dd |
Full text of other abbreviations
AIIC - Australian Inventory of Industrial Chemicals; ANTT - National Agency for Transport by Land of Brazil; ASTM - American Society for the Testing of Materials; bw - Body weight; CMR - Carcinogen, Mutagen or Reproductive Toxicant; DIN - Standard of the German Institute for Standardisation; DSL - Domestic Substances List (Canada); ECx - Concentration associated with x% response; ELx - Loading rate associated with x% response; EmS - Emergency Schedule; ENCS - Existing and New Chemical Substances (Japan); ErCx - Concentration associated with x% growth rate response; ERG - Emergency Response Guide; GHS - Globally Harmonized System; GLP - Good Laboratory Practice; IARC - International Agency for Research on Cancer; IATA - International Air Transport Association; IBC - International Code for the Construction and Equipment of Ships carrying Dangerous Chemicals in Bulk; IC50 - Half maximal inhibitory concentration; ICAO - International Civil Aviation Organization; IECSC - Inventory of Existing Chemical Substances in China; IMDG - International Maritime Dangerous Goods; IMO - International Maritime Organization; ISHL - Industrial Safety and Health Law (Japan); ISO - International Organisation for Standardization; KECI - Korea Existing Chemicals Inventory; LC50 - Lethal Concentration to 50 % of a test population; LD50 - Lethal Dose to 50% of a test population (Median Lethal Dose); MARPOL - International Convention for the Prevention of Pollution from Ships; n.o.s. - Not Otherwise Specified; Nch - Chilean Norm; NO(A)EC - No Observed (Adverse) Effect Concentration; NO(A)EL - No Observed (Adverse) Effect Level; NOELR - No Observable Effect Loading Rate; NOM - Official Mexican Norm; NTP - National Toxicology Program; NZIoC - New Zealand Inventory of Chemicals; OECD - Organization for Economic Co-operation and Development; OPPTS - Office of Chemical Safety and Pollution Prevention; PBT - Persistent, Bioaccumulative and Toxic substance; PICCS - Philippines Inventory of Chemicals and Chemical Substances; (Q)SAR - (Quantitative) Structure Activity Relationship; REACH - Regulation (EC) No 1907/2006 of the European Parliament and of the Council concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals; SADT - Self-Accelerating Decomposition Temperature; SDS - Safety Data Sheet; TCSI - Taiwan Chemical Substance Inventory; TDG - Transportation of Dangerous Goods; TECI - Thailand Existing Chemicals Inventory; TSCA - Toxic Substances Control Act (United States); UN - United Nations; UNRTDG - United Nations Recommendations on the Transport of Dangerous Goods; vPvB - Very Persistent and Very Bioaccumulative; WHMIS - Workplace Hazardous Materials Information System.
The information provided in this Safety Data Sheet is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guidance for safe handling, use, processing, storage, transportation, disposal and release and is not to be considered a warranty or quality specification. The information relates only to the specific material designated and may not be valid for such material used in combination with any other materials or in any process, unless specified in the text.